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Heat treatment, vacuuming, and insecticide application is considered the best method to eliminate bed bugs due to its comprehensive approach targeting these pests at various life stages.

Heat treatment is particularly effective because bed bugs are sensitive to temperature; exposure to temperatures above 120°F for an extended period will kill them, including their eggs. This method can penetrate furniture, carpets, and other hard-to-reach areas where bed bugs may hide.

Vacuuming plays a crucial role in physically removing bed bugs and their eggs from surfaces. It helps to reduce the population significantly and prepares the area for further treatment. However, it's important to dispose of the vacuum contents properly to prevent any re-infestation.

The application of insecticides enhances the effectiveness of these methods by providing a residual effect that helps eliminate any remaining bugs that were not killed by the heat treatment or manually removed through vacuuming. These insecticides are specifically formulated to target bed bugs, ensuring a more thorough eradication.

This integrated approach combines both physical and chemical strategies, addressing the problem on multiple fronts, which is essential for completely eliminating bed bugs and preventing their return.